Laszlo Nagy, M.D., Ph.D.

Dr Nagy is a physician by training and a molecular and cell biologist with a keen interest in solving clinically relevant basic biomedical problems related to epigenomics of cell identity, macrophage polarization and regenerative inflammation. He is also very passionate about team building and providing training and mentorship to the next generation of interns, students and  post-doctoral fellows including MD, PHD students. He has graduated 17 PhD students and 22  post-doctoral fellows, most of whom stayed in research or clinical medicine and  went on to work in  prestigious institutions.

My research interests focus on the cellular architecture of the human fetal-maternal interface. In particular, I am interested in fetal-derived placental resident macrophages, also known as Hofbauer cells (HBCs), their role in uncomplicated and complicated pregnancies, and how they interact with placental trophoblasts (TBs). In St. Petersburg, I participated in the collaborative project between the laboratory of Laszlo Nagy and the laboratory of Martin Trapecar, using Transwell co-cultures to study HBCs and TBs.

I study the inflammatory response of the innate immune system, focusing on the functions of dendritic cells and macrophages. Macrophages play essential roles in maintaining tissue homeostasis, and they are potential therapeutical targets in different immune disorders. I am aiming to utilize and integrate different methods of immunology, epigenomics, and biochemistry to investigate the cellular mechanisms of macrophage functions in health and disease.

Coming from Spain, I earned a PhD in Molecular and Cell Biology at the University of Oviedo, where I worked on the development of an advanced therapy for corneal endothelial dysfunction, bridging regenerative medicine and translational research. My work sparked a deep interest in how cellular identity and function are regulated, leading me to explore the role of nuclear receptors in immune responses. Now, as a postdoctoral researcher, I investigate how PPARγ and RXRs shape macrophage biology and lung inflammation, aiming to uncover new regulatory mechanisms with therapeutic potential.

My research focuses on how macrophage-specific transcription factors shape tumor microenvironment and regenerative inflammation. Using in vivo mouse models and genetic loss-of-function approaches combined with multi-omics profiling and molecular biology, I chart the cistromic and epigenomic programs of understudied factors and show how these chromatin landscapes drive macrophage subset specification and plasticity during tumor progression and tissue repair. Resolving the phenotype, mechanism, and spatiotemporal dynamics of these populations unveils actionable molecular targets to improve anti-cancer therapies with macrophage-centric immunotherapies.

I am an immunologist in training with a keen interest in the interdisciplinary convergence of immunology, mathematics, and technology. My main objective is to contribute to the advancement of regenerative immunotherapies, pushing the boundaries of this evolving field.
 

My research goals in the Nagy Lab focus on the intersection between molecular biology of immune resident macrophage and functional physiology in the lungs. Additionally, I am interested in how macrophages integrate different signaling molecules affect regeneration of skeletal muscle tissue, especially in Duchenne Muscular Dystrophy.

I am an undergraduate Biology student at the University of South Florida, specializing in Medical Biology. After starting as an intern, I now work as a lab assistant in the Nagy Lab, where I developed a passion for basic research under the mentorship of Dr. Nagy and Dr. Patsalos. I plan to further my education and pursue a career in fundamental scientific research.

Create and maintain a 3D organoid culture of a human placenta. This will allow us to study the mechanisms of placental development, and a route to identify how placental disorders can develop.

My name is Jordan, and I am a Ph.D. Student in the Nagy lab. My focus is on using nanoparticles for macrophage reprogramming for skeletal muscle regeneration. My research involves drug delivery and sustained release, immunoengineering, and regenerative medicine. Using this intersection, I hope to find new and effective solutions for volumetric muscle loss.

Mouse colony management and ordering.